In the United States, ovarian cancer is the most lethal gynecologic malignancy and represents the fifth leading cause of cancer death among women.
Ginger, a natural dietary component with antioxidant and anticarcinogenic properties. The ginger component -gingerol has been shown to exert anti-inflammatory effects in epithelial ovarian cancer cells. In a study, the effect of ginger on tumor cell growth and modulation of angiogenic factors in ovarian cancer cells in vitro were investigated.
The effect of ginger and the major ginger components on cell growth was determined in a panel of epithelial ovarian cancer cell lines. Activation of NF-κB and and production of VEGF and IL-8 was determined in the presence or absence of ginger.
Ginger treatment of cultured ovarian cancer cells induced profound growth inhibition in all cell lines tested. In vitro, 6-shogaol was found ti be the most active of the individual ginger components tested. Ginger treatment resulted in inhibition of NF-kB activation as well as diminished secretion of VEGF and IL-8.
In conclusion, ginger inhibited growth and modulates secretion of angiogenic factors in ovarian cancer cells. The use of dietary agents such as ginger may have potential in the treatment and prevention of ovarian cancer.
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